Do you know what type of ...

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Do you know what type of compound is causing the COD? That might change the answer,.

But, not knowing the exact chemistry, I would put an activated carbon bed followed by an ultraviolet TOC destruct unit and a micro-filtration tank ahead of your RO membranes. 

I have multiple Ultrapure water trains set up that way at my facility and get very good quality water from the ROs.

Good Luck