According to my knowledge, ...

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According to my knowledge, till now, I would propose Chlorine Dioxide  which is more effective than the widely used Chlorine on elimination of pathogens  does not react with organics, so it's use does not produce chloro-organics (-methane, - Ethan, etc.), is not consumed by organics retaining the full activity on bacteria attacks, and has many other secondary advantages which can be found in literature. 

The disadvantages of ClO2 is the higher cost comparing to Chlorine, and the need to be produced on site of application with a strictly adjusted dosing system and reactor.  Reagent 's misuse can react explosive. 

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Chlorine dioxide is not a practical solution for killing Cryptosporidium.  To produce a 2 log reduction of oocysts 553 ppm minutes has to be achieved i.e. at 1 ppm of ClO2 the contact time to produce the kill is 553 minutes.  If 0.5 ppm then 1106 minutes is required and this increases the colder the water is.  You are also limited by the combined level of ClO2 chlorate and chlorite of 0.5 ppm.

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